JDRF's Role

The number of people with diabetes whose situation is similar to Lilly's—who have genetic mutations resulting in a form of monogenic diabetes—is, unfortunately, small relative to the total number with type 1. Since these mutations were first recognized, several hundred cases have been discovered. But there are more.

JDRF is working with the NIH to provide information about a screening process so that people who were diagnosed as infants can be screened for mutations, and we are working with the scientists and doctors most closely involved with these forms of diabetes, such as the Comprehensive Diabetes Center at the University of Chicago, to create awareness so that people can learn about this opportunity, and to pursue science to see if we can dramatically expand the number of people with monogenic forms of diabetes that can be treated.

Please note that monogenic diabetes is not type 1 diabetes. Type 1 diabetes is a polygenic form of diabetes, and JDRF's resources are focused on finding a cure for type 1 diabetes and its complications. Nevertheless, research in monogenic diabetes may help elucidate some relevant mechanisms -- for example, some forms of monogenic diabetes are due to defects in pancreas development. Studying the genes involved may help identify pathways that lead to insulin-producing beta cell regeneration.

For additional information, you can call JDRF's Monogenic Diabetes Hotline at 1-866-780-0096. For information about clinical trials related to diabetes and genetics, see www.ClinicalTrials.gov.

You can help—donate now
To support research advances that can quickly and dramatically change the lives of people with diabetes for the better, click here.

Spread the word...
If you know anyone who might benefit from this information, please share this website with them: www.monogenicdiabetes.org.